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Technical Report | Medicine | India | Volume 12 Issue 11, November 2023 | Popularity: 4.9 / 10

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A Case of Thrombotic Thrombocytopenic Purpura

Dr. A Sankar, Dr. Umashankar, Dr. S. Adhitya Surya

Abstract: Thrombotic thrombocytopenic purpura (TTP) is a rare and life - threatening hematological disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and widespread microvascular thrombosis. We present a challenging case of TTP in a 45 - year - old female who initially presented with non - specific symptoms including fatigue, petechiae, and mild confusion. Laboratory investigations revealed severe thrombocytopenia, hemolytic anemia, and schistocytes on peripheral blood smear. Further evaluation led to the diagnosis of TTP, confirmed by the absence of ADAMTS13 activity and the presence of anti - ADAMTS13 antibodies. The patient was promptly initiated on therapeutic plasma exchange and corticosteroids, resulting in significant clinical improvement. However, her course was complicated by recurrent TTP episodes and the need for prolonged treatment, highlighting the complexities and challenges in managing this rare condition. This case underscores the importance of early recognition, timely intervention, and close monitoring in the management of TTP to improve patient outcomes.

Keywords: Thrombotic thrombocytopenic purpura, hematological disorder, microangiopathic hemolytic anemia, thrombocytopenia, schistocytes

Edition: Volume 12 Issue 11, November 2023

Pages: 763 - 766

DOI: https://www.doi.org/10.21275/MR231108113443

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