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Masters Thesis | Pathology | India | Volume 12 Issue 1, January 2023 | Rating: 5.2 / 10
PAP Smear and their Correlation with Cervical Biopsy
Dr. Divya Jyoti | Dr. Rohit Kumar [2] | Dr. Asim Mishra | Dr. Dipti Deb Barma
Abstract: Introduction: Cervical cancer is one of the most common forms of cancer worldwide. Screening women with regular Pap smear allows diagnosis of treatable pre-invasive and invasive lesions. Objective: The objective of the study was to correlate the Pap smear diagnosis with histopathology and to know the accuracy and efficacy of Pap smears in diagnosing premalignant and malignant cervical lesions. Material and methodology: This two year prospective study which was done in the Department of Pathology in ANMMCH, Gaya, includes 100 Pap smears for which histopathological diagnosis was also done. Method of sample selection was simple random sampling. After Pap smear examination, the cervical biopsies received from the same patients were also studied and then correlated with the diagnosis of Pap smears. Results: Out of 100 Pap smears, maximum cases were reported as NILM (64%), followed by ASCUS (6%), LSIL (10%), HSIL (15%), squamous cell carcinoma (4%) and 0.0% cases of adenocarcinoma were diagnosed. On histopathology, 69% cases were diagnosed as chronic cervicitis, CIN I (15%), CIN II and III (6.0%), squamous cell carcinoma (7%) and (0.0) % cases of adenocarcinoma were diagnosed. Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy was 88.89%, 87.32%, 72.73%, 95.38% and 87.55%. Conclusion: As per our study, maximum number of cases diagnosed on Pap smears correlated on histopathology, thereby concluding that Pap smears has an important role in diagnosis of cervical lesions.
Keywords: Cervix, Pap Smears, Cytology, NILM, LSIL, HSIL
Edition: Volume 12 Issue 1, January 2023,
Pages: 464 - 465