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Comparative Studies | Emergency Medicine | India | Volume 12 Issue 3, March 2023 | Rating: 5.1 / 10
Lactate Albumin Ratio in Comparison with Lactate to Predict Outcomes in Sepsis and Septic Shock
Albee, Anurag Prasad, Tapas Tripathi, Mohd Junaid Khan
Abstract: Background: It is important to have sensitive markers for predicting morbidity and mortality in patients with sepsis to improve the outcomes of such patients. The aim of this study was to assess the prognostic value of Lactate to Albumin (L/A) ratio with lactate alone. Methods: This was a single-center retrospective cohort study. Patients that had a suspicion of sepsis. The primary outcome was prolonged ventilatory days and in-hospital stay, with a secondary outcome of in-hospital mortality. Results: A total of 350 patients were included, of which most of the patients belonged to 40-50 years, and 56% were female.60% of patients were admitted to ICU, and of this 22.5% had ventilatory support for more than 7 days. The average in-hospital stay was 21+/-5.6 days. The overall in-hospital mortality rate was 34.5%, with that being related to septic shock being as high as 72%. The area under the curve value for lactate was 0.68 (at 95% confidence interval, it is 0.61?0.70, p < 0.05) and for the L/A ratio was 0.72 (at 95% confidence interval, it is 0.65?0.73, p < 0.05). The cutoff generated was 1.22 (sensitivity 62%, specificity 68%) for the L/A ratio in all septic patients The L/A ratio was a predictor of prolonged ventilatory days and in-hospital stay, as well as in-hospital mortality (OR 1.47, p < 0.05). Conclusion: The L/A ratio is a better prognostic indicator than lactate alone in patients with sepsis and septic shock for prolonged ventilatory stay, in-hospital stay, and in-hospital mortality.
Keywords: sepsis, lactate/albumin ratio, prognostic, in-hospital stay, prolonged ventilation
Edition: Volume 12 Issue 3, March 2023
Pages: 851 - 853