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Doctoral Thesis | Medical Science | India | Volume 12 Issue 5, May 2023 | Popularity: 5 / 10

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Study of Thyroid Dysfunction in Patient with Metabolic Syndrome in a Tertiary Care Centre of Kumaon Region

Swati Chamoli, Makrand Singh, Gaurav Yadav

Abstract: Background: Metabolic syndrome (MetS) is a clustering of multiple risk factors for atherosclerotic cardiovascular disease such as central obesity, impaired fasting glucose or type 2 diabetes mellitus, elevated triglyceride, reduced high - density lipoprotein cholesterol and hypertension. MetS is closely associated with thyroid dysfunction (TD) due to the impact of thyroid hormones on lipid metabolism, glucose, blood pressure, and cardiovascular dysfunction. This study was done to assess the underlying thyroid dysfunction among MetS patients and also to assess the clinical profile and demography of these patients. Methods: This was an observational study of 100 metabolic syndrome patients with thyroid dysfunction. Anthropometric measurements and vital signs were noted. Blood samples were tested for hemogram, correlogram, lipid profile, and thyroid function, and fasting plasma glucose. we aim to assess the underlying thyroid dysfunction among these patients. Results were analyzed by using percentages and proportions whenever possible. Results: A total of 100 patients with metabolic syndrome were taken among which 25 were males and 75 were females, most common age group affected was 40 - 49 years and 60 - 69years. Thyroid dysfunction was present in 27.0% of patients. Hypothyroidism was present in 23% of patients (Overt Hypothyroidism was 7% and sub - clinical hypothyroidism was 16.0%). In patients with metabolic syndrome diabetes was present in 78% of patients, systemic hypertension in 75%, and hypertriglyceridemia in 60% of patients. Conclusion: Hypothyroidism was the most common thyroid dysfunction in patients with metabolic syndrome. A large proportion of thyroid dysfunction cases diagnosed during the study highlight the need for vigilant thyroid screening in patients with metabolic syndrome.

Keywords: Atherosclerotic cardiovascular disease, Metabolic syndrome, Subclinical hypothyroidism, Thyroid dysfunction

Edition: Volume 12 Issue 5, May 2023

Pages: 314 - 318

DOI: https://www.doi.org/10.21275/MR23504200332

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