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Research Paper | Obstetrics and Gynecology | India | Volume 13 Issue 1, January 2024 | Rating: 5.2 / 10
A Comparative Study of Intravenous and Intramuscular Administration of Magnesium Sulfate in Eclampsia
Dr. Athulya Surendran | Dr. Jyotsna Deshmukh | Dr. Sonali Deshmukh [2]
Abstract: Introduction: Hypertensive disorder of pregnancy (HDP) is a common pregnancy complication involving the activation and injury of maternal endothelial cells. The Pritchard regimen is the standard protocol for managing eclampsia, and magnesium sulfate is the most popular anticonvulsant. This study aimed to evaluate the efficacy and advantages of intravenously administered magnesium sulfate for control of convulsion and prevention of its recurrence in women with eclampsia. Methodology: The study aimed to compare the efficacy and safety of an intravenous (Zuspan) and intramuscular (Pritchard's) magnesium sulfate regimen for pregnant patients presenting with eclampsia. The study population consisted of 80 pregnant patients above 20 weeks presenting with eclampsia at a tertiary care center. The study used a single blind randomized comparative study, with a sample size of 40 subjects in each group. The patients were divided into two groups: Group A, given the standard Pritchard's regimen (intramuscular), and Group B, given the standard Zuspan regimen (intravenous). Results: The study analyzed 80 pregnant patients above 20 weeks presenting with eclampsia at a tertiary care center. The majority of cases were primigravida?s, with 63.8% being multigravidas. The majority of cases were primigravida?s, with 63.7% being preterm. The study found no statistical difference in the control of convulsions or the need for additional doses after receiving the standard dose of MgSo4. Conclusion: Both intramuscular and intravenous magnesium sulfate regimens were effective in preventing convulsions in eclampsia cases. However, intramuscular magnesium sulfate has a higher incidence of magnesium toxicity, leading to complications like respiratory depression.
Keywords: Eclampsia, Hypertensive disorder of pregnancy, Maternal mortality, Pregnancy complications, Pritchard, Zuspan
Edition: Volume 13 Issue 1, January 2024,
Pages: 1777 - 1788