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Analysis Study Research Paper | Medical Science | India | Volume 13 Issue 2, February 2024 | Rating: 5.5 / 10
Pulmonary Function Abnormalities and their Association in Children with Beta-Thalassemia Major Age (10-18 years)
Dr. Jyoti Rani | Dr. Alka Yadav | Dr. Dhruva Chaudhary | Dr. Virender Gehlawat
Abstract: Objective: The objective of the study was to study prevalence of pulmonary function abnormality, severity and correlation with serum ferritin level. Materials and Methods: This was an observational Study done in tertiary care hospital setting, Inclusion criteria: Children with confirmed cases beta-thalassemia major aged 10?18 years on regular blood transfusion and chelation therapy for more than 6 years were included in the study. Exclusion criteria: Already diagnosed cases of pulmonary dysfunctions, CHD were excluded from the study. We performed a thorough clinical and physical examination before enrolling children to our study and blood sample were sent for Hb and serum ferritin before blood transfusion (BT). PFT was done within 24 h of BT using spirometer (Helios-401). Statistical analysis was done using SPSS (Version22). Results: 60 children enrolled in the study of age group 10 -18 year with M:F ratio 2:1. The pulmonary dysfunction was present in 33 (55%), but none of them had respiratory symptoms. The pulmonary dysfunction observed was restrictive 31 (51.7%), obstructive 1 (1.7%), and combined 2 (1.7%). A reduced forced vital capacity (FVC) % in 33 (73.3%). Risk factors such as, age at 1st transfusion, and serum ferritin level were significantly associated with pulmonary dysfunction (P< 0.05). There was no correlation between duration of chelation therapy. However, PFT values were found to be decreased in patients with a high serum ferritin (>2500 ng/ml), these differences were statistically significant. Conclusion: Abnormal patterns of lung function were common (restrictive type, predominant), even though none of these children had any respiratory symptoms.
Keywords: thalassemia major, pulmonary function abnormalities, restrictive abnormality, serum ferritin
Edition: Volume 13 Issue 2, February 2024,
Pages: 1290 - 1294