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Research Paper | Orthopaedic Surgery | India | Volume 13 Issue 4, April 2024 | Rating: 4.9 / 10
Role of Interleukin-1 in Patients with Pott's's Spine
Dr. Ajay Chandanwale | Dr. Kartik Sawalkar | Dr. Minish Katkar | Dr. Anant Gaikwad
Abstract: Background: Pott's spine is caused by Mycobacterium tuberculosis, a slow growing gram-positive, acid-fast bacillus which becomes lodged in the bone via Batson's venous plexus and lymphatic from primarily infected lung, lymph nodes, mediastinum and viscera, forming granulomatous inflammation and caseation necrosis. IL-1 plays many different roles, from mediating the immune response to infection6 to regulating vascular permeability and angiogenesis. But there is paucity of studies evaluating the relationship of Pots spine and interleukin 1, hence we have undertaken this study with the aim to assess the relationship between Interleukin-1 levels in patient with Pott's's spine. Aims & Objectives: To estimate the serum Interleukin 1 level in patients with Pott's's spine & determine its relationship with Pott's's spine. Methods: Present study was prospective in nature conducted among 37 patients of Pots spine. All patients fulfilling inclusion criteria and exclusion criteria were taken up for the study. Study was carried out over a period of 1.5 years. Serum Interleukin levels & CRP levels were assessed. Results: Majority of the patients was in the age group of 46-60 years and most of them were male. In this study, none of the cases had normal (0.1-5 pg/ml) interleukin 1 level while majority i.e. 16 (43.24%) of the cases had interleukin 1 level of 100.1-200 pg/ml. Mean interleukin 1 level in our cases was 165.49 + 89.54 pg/ml. Conclusion: High interleukin-1 level consistent with the better response to chemotherapy.
Keywords: interleukin-1 level, Pots spine, Mycobacterium tuberculosis, CRP
Edition: Volume 13 Issue 4, April 2024,
Pages: 871 - 874