Downloads: 3 | Views: 53 | Weekly Hits: ⮙4 | Monthly Hits: ⮙4
Analysis Study Research Paper | Anaesthesiology | India | Volume 13 Issue 5, May 2024 | Rating: 5.6 / 10
Attenuation of Pressor Response to Direct Laryngoscopy and Tracheal Intubation: Oral Clonidine Versus Oral Pregabalin as Pre - Medication
Dr. Nilesh Devatbhai Vaniya | Dr. Kiran Arashibhai Rathod
Abstract: Introduction: Direct laryngoscopy and tracheal intubation are noxious stimuli that can provoke undesirable responses in the cardiovascular, respiratory and other physiologic systems. This effect is more exaggerated when the patient has already preexisting diseases mainly coronary artery diseases, myocardial infarction, and intracranial aneurysm. Hence, to decrease this adverse effect of laryngoscopy and intubation, a number of drugs are used such as beta - blockers, lignocaine, and opioids. Material and method: This was prospective, double blind study conducted on 80 patients posted for elective surgeries under general anaesthesia. The patients were randomised into two groups to receive 200 microgram of clonidine in Group I and 150 mg of pregabalin in group II about 90 mins before induction of anaesthesia. Patients were observed for heart rate, systolic - diastolic - mean Blood Pressure response during endotracheal intubation and 1, 3, 5 and 10 minutes after intubation. Results: There were no significant difference in Heart rate at 1 minute post intubation in both the groups. Mean heart rate in the group receiving clonidine was lesser than the group receiving pregabalin. There was a significant lower systolic and mean BLOOD PRESSURE after intubation in pregabalin group. Hemodynamic stability is better with pregabalin group than clonidine group. Clonidine is better for attenuation of tachycardia response. Pregabalin group produced more sedation and relieved anxiety after premedication and post operatively compare to clonidine group. Conclusion: Pregabalin is better for hypertensive response control and more effective in attenuating anxiety and stress response to endotracheal intubation compared to Clonidine but tachycardia response is better attenuated by clonidine.
Keywords: Blood pressure, clonidine, direct laryngoscopy, heart rate, pregabalin, Tracheal intubation
Edition: Volume 13 Issue 5, May 2024,
Pages: 1567 - 1574