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Masters Thesis | Obstetrics and Gynecology | India | Volume 13 Issue 6, June 2024 | Popularity: 5 / 10

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Study of Serum Concentration of CA125 in Normal and Pre-Eclampsia Patients

Dr Yashika Anil, Dr Suma K B

Abstract: Objective: In this study, we wanted to evaluate the serum concentration of CA125 in pregnancies complicated by pre - eclampsia and normal pregnancies. Methods: This was a hospital based prospective observational study conducted among 120 pregnant women who came for antenatal check - up to the Department of Obstetrics & Gynaecology, JSS Hospital, Mysore, over a period of 18 months, from January 2021 to June 2022, after obtaining clearance from Institutional Ethics Committee, and written informed consent from the study participants. Results: Women with preeclampsia were primarily in the age range of 26 to 30 years, while women without preeclampsia were in the age group of 21 - 35 years.42 (70.0 %) women with preeclampsia and 32 (53.3 %) women without preeclampsia were preterm. The median CA125 among women with preeclampsia was 19 units/mL (17 - 28) and 10 units/mL (8 - 13) among those without preeclampsia. It was found that the difference was statistically significant. Conclusion: CA125 was found to be significantly elevated in preeclampsia group compared to normotensive group. Preeclampsia is linked to elevated maternal serum CA125 levels. Preeclampsia can be screened by using the biochemical marker CA125. Even though CA125 was increased in PE with severe features, it was not found to be associated with severity of the disease.

Keywords: CA125, Preeclampsia

Edition: Volume 13 Issue 6, June 2024

Pages: 146 - 151

DOI: https://www.doi.org/10.21275/MR24531132815

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