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Research Paper | Medicine | India | Volume 13 Issue 6, June 2024 | Rating: 4.4 / 10
A Case of Undifferentiated Connective Tissue Disease Presenting as Anemic Heart Failure
Dr. Shaurya Patel | Dr Arpita Aswinikumar Sahu
Abstract: UCTD is a connective tissue disorder, which does not meet the diagnostic criteria for a single disease. It is an autoimmune connective tissue disorder marked by serological autoimmune manifestations; UCTD can develop into a systemic autoimmune disease in 30% of patients as more diagnostic criteria are progressively met. The pathogenesis of UCTD is likely a combination of the autoimmune - mediated pathogenesis seen in single disease states. Here is the case of a 69 year old female who has a history of recurrent blood transfusion due to anaemia presented with chest pain, breathlessness and severe pallor. Last blood transfusion was one month back when the patient had been admitted with a haemoglobin of 3.5 and discharged with a haemoglobin of 8.5 post multiple whole blood transfusions. On lab investigations, Patient had a haemoglobin of 4 on admission and a retic count of 1.2% with low iron levels suggestive of iron deficiency anaemia but it could not explain the recurrent and rapid fall in Hb for which we did various investigations to rule out other types of anaemia and found ANA to be positive. On ANA profiling Centromere B was found to be positive suggestive of Systemic sclerosis or CREST syndrome but the patient did not meet the dia gnostic criteria for either hence leading to the diagnosis of Undifferentiated connective tissue disease. Patient was managed with Hydroxychloroquine and Steroid and advised a Rheumatologist Opinion.
Keywords: Undifferentiated Connective Tissue Disease; Connective tissue disease; Anaemia of chronic disease
Edition: Volume 13 Issue 6, June 2024,
Pages: 1807 - 1809