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Research Paper | Pathology | India | Volume 13 Issue 9, September 2024 | Popularity: 5.7 / 10
Study of Haemoglobinopathies in Paediatric Age Group by High Performance Liquid Chromatography in a Tertiary Care Hospital in Gujarat
Dr. Janhaviben Makwana, Dr. Surbhi Chaudhari, Dr. Kirit Jadav
Abstract: Introduction: Anemia is a major health problem in pediatric populations of India.Many factors are responsible for childhood anemia, like undernutrition, iron and vitamin deficiency, tuberculosis, HIV, chronic infections, malaria etc. Inherited hemoglobin disorders are the most common genetic disorders and their frequency and distribution varies among different racial and ethnic groups. In developing countries like India, it causes financial burden too. Aims and Objectives: This cross-sectional study was undertaken with an aim to detect haemoglobinopathies in paediatric age group in S.S.G. Hospital Baroda, Gujarat. Method: A total of 250 cases were taken of paediatric patients suspected of haemoglobinopathies. Clinical data including complete history, CBC, RBC Indices, peripheral smear findings and HPLC findings were taken. Haemoglobin typing was done by HPLC with BioRad variant II machine using EDTA samples of above mentioned paediatric patients. Results: The prevalence of Hemoglobinopathies was found to be 64.4% in the present study with sickle cell trait being the most common abnormal haemoglobin detected followed by sickle cell disease, beta thalassemia trait, beta thalassemia major and heterozygous for HbD Punjab and sickle cell disease. Conclusion: Chronic anemia cases should be screened for hemoglobinopathies. As the definitive treatment of hemoglobinopathies is still difficult to avail, genetic councelling should be considered for hrmoglobinopathy patients and their families to prevent new cases. HPLC is reliable and cost effective method for detection of various hemoglobinopathies and thalassemia.
Keywords: Haemoglobinopathies, High performance liquid chromatography, HPLC, Thalassemia
Edition: Volume 13 Issue 9, September 2024
Pages: 755 - 757
DOI: https://www.doi.org/10.21275/MR24912165342
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