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Analysis Study Research Paper | General Surgery | Indonesia | Volume 13 Issue 9, September 2024 | Popularity: 5.1 / 10

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Systematic Review of Hyperbaric Oxygen Therapy in Burn Management: A Comprehensive Analysis from Past to Present

Yulius Arthur Chietra, Mendy Hatibie Oley

Abstract: Background: Burn injury historically carried a poor prognosis, affecting several organ beyond the skin. Amongst various interventions for burns, hyperbaric oxygen therapy (HBOT) was proposed as a game changer since the spearhead in 1965, a lot of well - experimental studies, clinical work has been done and been extensively integrated as an adjunctive treatment for its therapeutic properties in reducing hypoxia, inflammation, reperfusion injury and promotes neovascularization. Improved and accelerate wound healing as well as a reduction of morbidity and mortality after burn injury are expected. However, in spite of numerous undisputedly positive results regarding the effectiveness of adjunctive HBOT for burn injury, the method has not yet been established in clinical routine. This review aims to identify the efficacy of HBOT as an adjunctive therapy in burns. Materials and Methods: PRISMA guidelines were followed to identify studies. Sources for this review were collected by searching PubMed, Embase, Google Scholar, Cochrane Library, and Garuda in any time frame. The information was compared and bandied to generate an up to date conclusion. Results: 55 publications (38 animal experiments, 4 trials in human volunteers and 13 clinical studies) were included in this review. All were able to show a profound effects of HBOT, most of them describing reduced edema, increased microvascularity, improved epithelialization, significant reduction of bacterial growth. Secondary burn wound progression was prevented, as microvascular perfusion could be preserved, and cells were kept viable on stasis zone. Conclusion: HBOT presents a promising adjunctive treatment for burn injuries, with potential to enhance healing, reduce complications, and improve patient outcomes. Continued research that focus on outcome measures, wound healing time, complications, mortality rates, and scar quality is necessary to establish standardized treatment protocols and confirm long - term benefits. As the field evolves, HBOT may become an integral part of burn care in specialized centers.

Keywords: hyperbaric oxygen therapy, hyperbaric oxygen, burns, review

Edition: Volume 13 Issue 9, September 2024

Pages: 793 - 800

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