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Research Paper | Biochemistry | India | Volume 14 Issue 1, January 2025 | Popularity: 5.6 / 10

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Association of Serum Insulin Levels with Fasting Blood Glucose in Type 2 Diabetes Mellitus Patients: A Cross - Sectional Study

Arvind Kumar Gupta, Raashika Saxena, Simran Bamniya

Abstract: Background: Type 2 Diabetes Mellitus (T2DM) is characterized by hyperglycemia due to insulin resistance and impaired ? - cell function. The relationship between fasting serum insulin levels and fasting blood glucose (FBG) is pivotal for understanding disease pathophysiology. Objectives: In this study, we aimed to analyze the association between fasting serum insulin levels and fasting blood glucose in patients diagnosed with T2DM. Materials and Methods: A hospital - based cross - sectional study included on 50 T2DM patients aged 20 - 65 years. Fasting serum insulin and blood glucose levels were measured after overnight fasting. Insulin resistance was calculated using the HOMA - IR index and correlation analysis were performed. Results: Fasting serum insulin was significantly correlated with HOMA - IR (p = 0.03), indicating its role as a surrogate marker of insulin resistance. However, no significant association was found between fasting blood glucose and fasting serum insulin in this cohort. Conclusion: The findings highlight the complexity of insulin - glucose dynamics in T2DM and underscore the importance of targeting insulin sensitivity to manage glycemic dysregulation effectively.

Keywords: Type 2 Diabetes Mellitus, Insulin Resistance, HOMA - IR, Glycemic Control, Hyperinsulinemia

Edition: Volume 14 Issue 1, January 2025

Pages: 356 - 359

DOI: https://www.doi.org/10.21275/MR25108214204

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