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Research Paper | Immunology | United States of America | Volume 5 Issue 5, May 2016 | Rating: 6.5 / 10

Burden of Lupus Nephritis among Patients Managed in Routine Clinical Practices in Europe

Siva Narayanan MS MHS

Abstract: Assessing the characteristics of patients with Lupus Nephritis (LN) in comparison to those without LN among patients with systemic lupus erythematosus (SLE) could help portray LN disease burden. A multi-center chart review of adult SLE patients was conducted among rheumatologists/internal medicine physicians in UK/France/Germany/Italy/Spain (EU5) to collect data on disease characteristics and treatment patterns.168 LN patients and 569 non-LN patients with SLE were analyzed. Among LN/Non-LN cohorts, % currently receiving care in in-patient setting was14.9/8.8, % hospitalized >=1 in the past-year was49.4/29.7. Clinical burden (patients experiencing a flare, low C3/C4, higher SELENA-SLEDAI scores) and humanistic burden (diminished ability to perform every-day tasks, interact fully with family and friends, or work/keep employment) was higher among LN cohorts. Factors influencing the observed burden, including the therapeutic strategies used in these geographies warrant further investigation to manage LN optimally.

Keywords: Lupus Nephritis, Burden, Flares, Hospitalizations, Europe

Edition: Volume 5 Issue 5, May 2016,

Pages: 1364 - 1367