International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 102 | Views: 269

Research Paper | Biochemistry Science | Saudi Arabia | Volume 5 Issue 6, June 2016 | Popularity: 6.7 / 10


     

Predictive Biomarkers of Hepatocellular Carcinoma in Sudanese Patients with Liver Cirrhosis

Eman Kabbara, Mudawi HM, Abdelraheem Osman Mohamed, Abozer Y Elderdery, Hamdan Z Hamdan, Sayed Ibrahim Ali, Ahmed Mohamedain Eltom


Abstract: Liver cirrhosis (LC) is a prevalent condition in Sudan and the main predisposing factor for hepatocellular carcinoma (HCC). This study assesses the effectiveness of the use of -fetoprotein (AFP), ultrasound (US), AFPmRNA in addition liver enzymes as early predictors for hepatocellular carcinoma (HCC) in Sudanese patients with liver cirrhosis (LC). Methods A Hundred patients with LC, 25 patients with confirmed HCC and 50 healthy controls were included in the study. Serum AFP, AFPmRNA and liver enzymes were determined annually in patients with liver cirrhosis in addition to abdominal U/S for 3 years. Serum AFP was determined using enzyme immunoassay (EIA) in patients and controls. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used for detection of AFPmRNA. Results During follow up hepatic nodules were identified in three liver cirrhotic patients (3 %). AFP detection rate was higher (64 %) at a low cut-off point (20ng/dl). the AFPmRNA had a very low sensitivity (24 %) in HCC group. Only 3 patients developed HCC additionally to LC after follow up and all had positive AFPmRNA and AFP Conclusions In conclusion the combination of U/S, AFP and AFPmRNA would be the most effective tool for HCC screening in Sudan. However, AFPmRNA alone had the lowest detection rate and is therefore not recommended for screening.


Keywords: hepatocellular carcinoma, -fetoprotein, AFPmRNA, ultrasound, liver cirrhosis, Sudan


Edition: Volume 5 Issue 6, June 2016


Pages: 1084 - 1088


DOI: https://www.doi.org/10.21275/NOV164334



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Eman Kabbara, Mudawi HM, Abdelraheem Osman Mohamed, Abozer Y Elderdery, Hamdan Z Hamdan, Sayed Ibrahim Ali, Ahmed Mohamedain Eltom, "Predictive Biomarkers of Hepatocellular Carcinoma in Sudanese Patients with Liver Cirrhosis", International Journal of Science and Research (IJSR), Volume 5 Issue 6, June 2016, pp. 1084-1088, https://www.ijsr.net/getabstract.php?paperid=NOV164334, DOI: https://www.doi.org/10.21275/NOV164334



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