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Review Papers | Biology | Canada | Volume 5 Issue 6, June 2016 | Popularity: 6.6 / 10
Improving Neuro-Regeneration Efficiency in the Stem Cell Treatments of Parkinson's Disease: Fetal Tissue vs. Mesenchymal Stem Cell
Mohammad Reza Ghaemi
Abstract: This research reviews the treatment concept and procedures that are currently being practiced and studied on patients using stem cell grafts of fetal tissue as well as mesenchymal stem cells, alongside the nature of neurogenesis phenomenon in correlation with subventricular zone architecture in individuals with Parkinsons disease in order to evaluate which treatment procedure has a higher efficiency rate in terms of neuro-regeneration capacity. This research also suggests considering the condition of subventricular zone prior to stem cell transplant since the neurogenesis process in human brain is compromised due to already impaired structure of subventricular zone as a result of dopamine depletion and lack of growth factors regulatory effect, a precondition that could improve the efficacy of stem cell therapies for treatment of Parkinsons disease.
Keywords: Subventricular zone, Fetal tissue graft, Mesenchymal stem cells, Neural stem cells, Neurogenesis
Edition: Volume 5 Issue 6, June 2016
Pages: 1259 - 1269
DOI: https://www.doi.org/10.21275/NOV164455
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