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Research Paper | Pharmacy | India | Volume 9 Issue 4, April 2020 | Popularity: 7.3 / 10

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Formulation and Evaluation of Fast Dissolving Oral Film of Losartan Potassium

Mahesh Thakare, Vaibhav Narwade, Vishal Rasve, Vijay Chakote

Abstract: Losartan potassium is an angiotensin-receptor blocker (ARB) used in the management of hypertension. The purpose of this research work was to formulate a fast dissolving film of Losartan potassium for the treatment of hypertension, by using polymers such as Hydroxy Propyl Methyl Cellulose E15 (HPMC) and Hydroxy Propyl Methyl Cellulose E5 (HPMCE5) in different concentrations. Films of Losartan potassium were prepared by solvent casting method using polymers such as HPMC E15 and HPMC E5 in different ratios. Propylene glycol and Glycerine was used as a plasticizer. The prepared films were subjected to different evaluation parameters like morphological properties, film thickness, folding Endurance, Surface pH, content uniformity, in vitro disintegration time and in vitro dissolution studies. The optimized formulation was subjected to stability studies, revealed that no significant changes occurs after 1 month of test period. Results of FTIR data of optimized formulation (X5) revealed that there was no incompatibility observed between the drug and excipients used in the formulation. These findings suggest that the fast dissolving oral film containing Losartan potassium is considered to be potentially useful for the treatment of Hypertension where quick onset of action is desirable.

Keywords: Fast dissolving Film, HPMC E15, HPMC E5, Solvent - casting method

Edition: Volume 9 Issue 4, April 2020

Pages: 831 - 837

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