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Research Paper | Pharmacology and Toxicology | India | Volume 10 Issue 11, November 2021 | Rating: 4.7 / 10
Anti - Ulcer Activity of Ficus benghalensis Linn Stem Bark Ethanolic Extract in Rats
Priti Yadav | Vishal Dubey [2] | Ajay Diwakar | Megha Tiwari
Abstract: The study was perform to evaluate the antiulcer activity of ethanolic extract of Ficus benghalensis LINN stem bark in gastric ulcer effected rats. Anti - ulcer activity was evaluated via oral administration of ethanolic extract of Ficus benghalensis LINN stem bark at the dose are given 250, 500 and 1000mg/kg thrice per day for 5 days before pyloric ligation ulceration and indomethacin induced ulceration. In indomethacin and pyloric ligation model, the pre - treatment with ethanolic extract of Ficus benghalensis LINN stem bark and ranitidine significantly reduce the ulcer index, free acidity as compared with controlled group. The % protection of ulcers were evaluated. The extract showed significantly (P<0.05) increase in pH with significant decrease in volume of gastric juice, free and total acidity. Histopathological findings also confirm the antiulcer activity of ethanolic extract of Ficus benghalensis LINN stem bark in albino wistar rats. The present study showed that ethanolic extract of Ficus benghalensis LINN stem bark have anti - ulcer activity in 2 models. The various chemical constituents are present in Ficus benghalensis such as carbohydrates, phenols, tannins, flavones saponins, steroids, Quinones, bengalenosides, leucocyanidin glycoside, terpenoids and cardiac glycosides. These compounds have various pharmacological activities such as antioxidant, antimicrobial, anticancer, antiulcer, analgesic, antipyretic, antidiarrhoeal, anti - Tumor, immunomodulatory activity.
Keywords: Antiulcer activity, Ficusbenghalensis bark extract, pyloric ligation model, indomethacin induced ulceration, ranitidine
Edition: Volume 10 Issue 11, November 2021,
Pages: 626 - 629