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Research Paper | Medical Science | Gambia | Volume 11 Issue 11, November 2022 | Rating: 4.9 / 10
Evaluation of the Impact of Insulin, Ocimumgratissimum and Verononia amygdalina on Hemoglobin Concentration in Type 1 Diabetic Rats: A Comparative Study
Abstract: Decreased hemoglobin (Hb) concentration has been implicated in patients with diabetic nephropathy, due to impaired ability of kidney to produce erythropoietin (EPO). Several in vivo studies have also reported varying results on the effect of herbal remedies like Ocimumgratissimum (OG) and Verononia amygdalina (VA) on hemoglobin concentration. So far, there is no sufficient evidence or data for an effective therapy for anemia in type 1-diabetes (T1D). To compare the impact of insulin, OG and VA on Hb concentration in type 1-diabetes, type I diabetes was induced using 65 mg/kg STZ. Once diabetes once established by testing with a glucometer, insulin, OG and VA were administered and compared with negative and positive controls. Hb concentrations for the various groups were measured using Ion-Exchange Resin Method and the results analysed using One Way ANOVA. Insulin caused significant (P? 0.05) increase in Hb concentration when compared to controls, OG and VA treated groups. However, there was a significant (P? 0.05) increase in Hb concentrations in non-diabetic rats treated with VA, when compared with negative control. It could be concluded that Insulin is effective in treating anemia in uncomplicated T1D while VA significantly increase Hb in healthy states and could be evaluated for the treatment of anemia in humans.
Keywords: Insulin, Ocimumgratissimum, Verononia amygdalina, Hemoglobin and Type 1-diabetes
Edition: Volume 11 Issue 11, November 2022,
Pages: 224 - 227