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Research Paper | Medicine | Indonesia | Volume 11 Issue 10, October 2022 | Popularity: 4.8 / 10

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The AST / Platelet Ratio are a Predictor of Liver Injury and its Association with Lactic Acid Levels in Pediatric Sepsis Patients Admitted to the Hospital. H. Adam Malik, Medan

Munawwar, Dwiputri AL, Aman AK

Abstract: Introduction: Sepsis-associated liver injury (SALI) is one of the main clinical manifestations of sepsis, as well as an independent risk factor for multiple organ dysfunction syndrome and mortality in pediatric sepsis. The early warning biomarkers for identifying SALI remain poorly defined. Objective: To analyze the relationship between aspartate aminotransferase to platelet ratio index (APRi) and Lactate liver injury occurrence in pediatric sepsis, as well as determine the APRi cutoff value for early identification of SALI. Methods: This research is an observational study with a cohort?prospective data collection method. This study took blood samples of patients who were treated at Hospital as many as 26 patients. Samples were examined for AST/Platelet and lactate ratio on days 1 and 3. The study was conducted after obtaining ethical approval and informed consent. Result: 17 boys (73.1%) and 7 girls(26.9%) with the youngest age 1 month and the oldest 17 years. A total of 17 people (65.4%) children showed liver injury. By using the Spearman correlation test, it was shown that there was no significant correlation between APRi and lactic acid on the first day(p=0,252) and the third day(p=0,883). The results of the analysis using the ROC curve showed that APRI could be used to predict liver injury in pediatric patients with sepsis (p<0.05). With APRI cut off day I and day III which are 1.86 and 2,075. Discussion: SALI and lactate is one of the main clinical manifestations of sepsis, an independent risk factor for multiple organ dysfunction syndrome (MODS) and mortality in pediatric sepsis Conclusions and suggestions: APRI scores can be used to predict liver injury in pediatric patients with sepsis. Further research is needed to outline one by one the factors that contribute to the occurrence of liver injury in pediatric sepsis patients and are associated with PELOD scores to assess mortality of pediatric patients with sepsis.

Keywords: Sepsis, APRI Score, Lactate, Liver Injury

Edition: Volume 11 Issue 10, October 2022

Pages: 1259 - 1266

DOI: https://www.doi.org/10.21275/SR221024100834

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