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Research Paper | Medicine | Indonesia | Volume 12 Issue 3, March 2023 | Rating: 5 / 10
Association of Inflammatory Markers with Acute Respiratory Distress Syndrome in Severe and Critical Degree COVID-19 Patients
Eva Susanti Debora Hutabarat | Fajrinur Syarani [3] | Syamsul Bihar [3] | Putri C. Eyanoer
Abstract: Background: One of the most prevalent COVID-19 consequences, with a high fatality rate, is acute respiratory distress syndrome (ARDS). ARDS manifests as an organ malfunction during COVID-19's hyperinflammatory phase. However, there is a scarcity of information on the clinical features and inflammation markers of people with severe COVID-19 and ARDS. Therefore, this research aimed to evaluate the association of inflammatory markers with COVID-19-associated ARDS among patients hospitalized with COVID-19 cases in H Adam Malik Hospital Medan. Methods: This is an analytical cross-sectional study from 204 medical records on patients hospitalized with a confirmed COVID-19 with a severe and critical degree in RSUP H Adam Malik Medan between February and July 2021. The chi-square test was conducted to analyze the data with SPSS version 25. Results: We analyzed laboratory tests to identify the inflammatory marker in 204 COVID-19 majoritieswho were male (119 vs 85) admitted to the Department of Pulmonology and Respiratory Medicine, Adam Malik General Hospital. We investigated the association between inflammatory markers and ARDS. According to statistical research, neutrophilia is associated with a greater neutrophil-to-lymphocyte ratio (NLR) and high levels of the procalcitonin were associated risk factor for ARDS event (respectively: PR: 1.685, 95%CI: 1.651-5.486, p<0.05; PR: 1.515, 95%CI: 1.664-5.409, p<0.05; PR: 1.517, 95%CI: 1.731-5.705, p<0.05). Conclusion: There were associations between inflammatory markers with ARDS. Neutrophilia, elevated NLR, and high levels of procalcitonin prior to hospitalization could be considered risk factors for ARDS in severe COVID-19 allowing clinicians to adjust treatment strategies aggressively to reduce mortality.
Keywords: SARS-CoV-2, COVID-19, ARDS, inflammation markers, Indonesia
Edition: Volume 12 Issue 3, March 2023,
Pages: 621 - 623