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Review Papers | Cancer Science | Bangladesh | Volume 12 Issue 2, February 2023 | Rating: 5.7 / 10
A Literature Review on Development and In-Situ Evaluation of Nanocrystal Formulation of Docetaxel Anticancer Drug
Shahadat Hossain
Abstract: The purpose of this perusal is to nanocrystal formulation of the anticancer drug and enhance its biological activity can be augmented by Docetaxel. Docetaxel is used to treat advanced or metastatic (that has spread) cancer and other cancer in patients who have previously received other cancer medicines that did not work well. It is a strong chemotherapy drug; also has small side effects. Nanodimension changes physical properties of Docetaxel which were used in pharmaceutics to develop a new innovative formulation principle for poorly soluble drugs: the drug nanocrystals. Docetaxel solubilized in a Tween 80/ethanol solution in inhibiting tumor growth without toxicity. Due to their particle size, nanocrystals (nanosuspension) have the great advantage of being intravenously injectable, reaching 100% bioavailability. The nanocrystal formulation of Docetaxel drug provides an achievements in improving the bioavailability of poorly soluble drugs which accounts for nearly 40 % newly discovered drug molecules and its nanocrystal efficacy is more than 98% according to their administration route, describes the methods developed to overcome physicochemical and stability - related problems, that are able to modify the drug delivery, penetrate targeting specific organs or cells, and enhance the bioavailability. The primary mechanism of docetaxel action is direct bonding to the ? - subunits of tubulin, promoting the stabilization of tubulin polymerization and inhibition of microtubule depolymerization. Nanocrystal formulation of docetaxel is a rapidly metabolized drug; enhancing its in vivo circulation may benefit its therapeutic efficacy.
Keywords: In - situ, Nanocrystal, nanocrystal formulation, Docetaxel, anticancer drug, nanodimension, nanomedicine, nanoscience, nanotechnology, taxane, cancer, nanoparticle, microtubules, pharmacokinetics, Cancer Immunotherapy, vivo circulation, drug delivery, targeting cells, metastatic
Edition: Volume 12 Issue 2, February 2023,
Pages: 1171 - 1181