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Research Paper | Surgery | India | Volume 11 Issue 11, November 2022 | Popularity: 5.1 / 10

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Effect of Prophylactic Use of Ciprofloxacin and Metronidazole in the Outcomes of Acute Pancreatitis

Dr. Sabyasachi Behera, Dr Krishna Murari, Dr Pritam Marandi

Abstract: Background: One of the major causes of death in cases of severe acute pancreatitis is SIRS and MODS. Prophylactic antibiotics are known to reduce the septic complications in these cases. The aim of this study is to assess the efficacy of prophylactic use of Ciprofloxacin and metronidazole in reducing complications and mortality in severe acute pancreatitis. There are new concepts and developments in the diagnosis and management of acute pancreatitis. Current evidence suggests that there is no role of prophylactic antibiotics use in acute pancreatitis. However, it is very common to use prophylactic antibiotics in our setting. Method: This is a comparative two-armedstudy design done in the period between April 2021to March 2022 in the department of General Surgery at RIMS Ranchi, involving 80 patients admitted with a diagnosis of acute pancreatitis in the inpatient ward of department of General Surgery at RIMS Ranchi.Patients were randomized into two groups ie, one receiving combination of iv Ciprofloxacin and metronidazole and other receiving normal saline as placebo; both started at the day of admission, and given for next 10 days. The occurrence of local and septic complications, mortality rate and length of stay were recorded and compared in both groups. Result: There were no significant differences between both the groups of patients of acute pancreatitis in the outcomes. Conclusion: The use of prophylactic ciprofloxacin and metronidazole is not associated with any significant clinical improvement, and thus its use can be avoided in routine clinical practice.

Keywords: Acute pancreatitis, Ciprofloxacin-metronidazole, clinical outcome

Edition: Volume 11 Issue 11, November 2022

Pages: 1440 - 1442

DOI: https://www.doi.org/10.21275/SR221128222848

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