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Comparative Studies | Pharmacotherapeutics | India | Volume 11 Issue 12, December 2022 | Rating: 5.1 / 10

A Comparative Study of Oral Nifedipine and Oral Labetalol in the Treatment of Pregnancy-Induced Hypertension

Acharya Tonima | Pradhan Subhrasmita | Das Rashmi | Pandey Sachchidanand

Abstract: Background: Hypertensive disorders of pregnancy impact on maternal and neonatal mortality and morbidity. Various anti-hypertensive drugs have been used such as methyldopa, nifedipine, labetalol and hydralazine for treatment of pre-eclampsia. Aim: To compare the efficacy and safety of oral Labetalol with oral Nifedipine in the management of pre-eclampsia. Methodology: This is a longitudinal study in which 100 pregnant women diagnosed with pregnancy induced hypertension in severe pre-eclampsia in labour room were enrolled. Patients were given Nifedipine 10mg stat orally and BP was checked every 5min and repeat dosing was considered after 15-20min. Similar method was followed for oral Labetalol but with a dose of 100mg and BP was checked every 5min till target BP was achieved. Patients of both the groups were observed in the hospital till delivery. Results: In the present study there is a significant decline rate in diastolic BP in both the groups (p<0.05). But, the group that received oral Labetalol showed more decline rate (13.5%) as compared to the group receiving oral Nifedipine (13.2%). Conclusion: Hypertensive disorder of pregnancy is one of the life-threatening complication encountered in obstetrics and globally is major cause of maternal morbidity and mortality. Management of acute severe hypertension in pregnancy is challenging. Present study compares the efficacy and safety profile of oral Nifedipine and oral Labetalol in reaching the therapeutic goal. From the results of the study, we can conclude that oral Labetalol is more efficacious.

Keywords: Labetalol, Nifedipine, Hypertension, Pregnancy, Pre-eclampsia

Edition: Volume 11 Issue 12, December 2022,

Pages: 461 - 464