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Research Paper | Chemistry | Nigeria | Volume 11 Issue 3, March 2022 | Popularity: 4.7 / 10

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Spectral Studies and Antimicrobial Activities of Novel Synthesized Oxovanadium (IV) Complexes with Steroid Ligands

Uchenna P. Ogodo, Olufunso O. Abosede

Abstract: Two novel vanadyl complexes (ML) with steroid ligands (betamethasone and prednisolone) have been successfully synthesized at ambientconditionsusing suitable solvents,where M is VOIV and L is betamethasone or prednisolone. The complexes were synthesized by reacting VOSO4 and the corresponding ligands in 1:2 molar ratio. The synthesized compounds were structurally characterized by their melting point, UV-Vis, and FT-IR spectra. The spectral features of the new complexes [VOIV(Prd)2] (1) and [VOIV(Beta)2] (2) confirm the formation of the complexes. The synthesized complexes were further screened against microbial growth with different cultures which disclosed the potency of the new compounds. The complexes possess higher antimicrobial potencies against Proteus mirablis and Salmonellatyphithan betamethasone and prednisolone ligands even at concentrations lower than the MIC values.

Keywords: Oxovanadium (IV), prednisolone, betamethasone, metal complex, FTIR, antimicrobial

Edition: Volume 11 Issue 3, March 2022

Pages: 625 - 630

DOI: https://www.doi.org/10.21275/SR22311160759

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