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Research Paper | Pharmacy | Indonesia | Volume 11 Issue 8, August 2022 | Popularity: 5 / 10

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The Effectiveness of Porang (Amorphophallus oncophyllus) Powder Solution on Healing Inflammation of The Stomach of Wistar Rats (Rattus norvegicus) induced with Acetic Acid

Eko Suyoko, Dingse Pandiangan, Mihael Valery Tumbol, Nelson Nainggolan, Elvina Artha Nainggolan, Verina Putri Gloria Nainggolan

Abstract: Research was conducted to test the effectiveness of arum Amorphophallus oncophyllus flour solution containing glucomannan in curing acetic acid induced gastric wound in wistar rats (Rattus norvegicus). Previous studies emphasize the anti - inflammatory characteristics of A. oncophyllus. The experiment was conducted in vivo with wistar rats with completely randomized design. Observed parameters were morphology plant, activity of rats, body weight (g), stomach size (cm) and gastric mucosal layer before and after induction and treatment on 1st, 7th, and 14th day. The rats were grouped into control (normal), negative control, positive control and treatments groups. The observed parameters showed that A. oncophyllus flour solution has the potential to cure gastric inflammation induced by acetic acid by 25%concetration, with a dose as big as 1.25 mL for 3 days.3 mL of arum flour solution per day showed great potential and effectiveness in healing diseases and gastric wounds in wistar rats within the 7 days in comparison with the positive control of gastric drugs. This research indicates that A. oncophyllus has the potential to be developed as an original Indonesian drug for the treatment of gastric inflammation.

Keywords: Stomach Ulcer, Gastric Inflammation, Amorphophallusoncophyllus, Wistar Rats

Edition: Volume 11 Issue 8, August 2022

Pages: 465 - 472

DOI: https://www.doi.org/10.21275/SR22804235551

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