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Review Papers | Chemistry | India | Volume 11 Issue 9, September 2022 | Rating: 5 / 10

Synthesis and In-Vitro Screening of Novel Calcium Channel Blocker's for Antihypertensive Activity

Tripti Kshatri | K. P. Namdeo

Abstract: Pyrimidine plays a significant role among other heterocycles. From the literature survey, in recent years the design of 3, 4-dihydropyrimidin-2(1H)-ones nucleus have been attracted for considerable interest because of their therapeutic and pharmacological properties. Pyrimidine nucleus was synthesized by Biginelli reaction. This product was subjected for alkaline ester hydrolysis and these derivatives on treatment with thionyl chloride and substitution by different secondary amines produced final desired compounds. The remaining compounds have been synthesized by above method. The purity of the compounds has been checked by TLC monitoring and the conformation of structure was confirmed by different spectra like UV, IR, NMR, Mass etc. The in-vitro antihypertensive and calcium channel blocking activity have been done by IC50 measurement method with nifedipine as standard.

Keywords: 3, 4-dihydropyrimidin -2(1H)-ones, Biginelli reaction, Antihypertensive and Calcium channel blocking activity, IC50, Nifedipine

Edition: Volume 11 Issue 9, September 2022,

Pages: 786 - 789