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Research Paper | Medicine Science | India | Volume 11 Issue 12, December 2022 | Rating: 5.2 / 10
Serum Levels of IL-1?IN Patients Presenting with Cardiac Dyspnoe and their Association with NYHA Functional Classification
Dr. Smita Deokar | Dr. Neelam Redkar | Dr. Prakash Relwani | Dr. Naina Dalvi
Abstract: Objectives: A growing body of evidence suggests that inflammation plays the key role in various cardiac diseases. Heart failure (HF) is the leading cause of morbidity and mortality in developed as well as developing countries which is a devasting disease. Despite significant advances in the prevention and treatment of HF, the prognosis is still poor. Serum levels of some cytokines are elevated in patients with chronic heart failure. But very few studies have been done so far in relation to the role of interleukin-1? in cardiac patients whose symptoms ranged from New York Heart Association functional class I to IV. We aimed to determine serum interleukin-1? levels in different cardiac diseases along with NYHA categorisation. Materials and methods: The study population of 229 cases of CVD's who were enrolled at Cardiology and Medicine Department along with 229 age and sex matched healthy controls were included for serum analysis of interleukin-1?. Results: A total of 458 patients were included in the study. Serum interleukin-1? was significantly [median (IQR) 2.5 (5.2) pg/mL] increased inNYHA class IV i. e., in severely symptomatic patients compared to NYHA class II [median (IQR) 0 (3.1) pg/mL]& III [median (IQR) 0 (3.0) pg/mL]. Conclusion: There is a strong correlation between Serum IL-1? and the extent of to NYHA classification in patients with documented CVD. Elevated Serum IL-1? was increased in higher NYHA classes.
Keywords: Cardiovascular diseases, ELISA, Heart failure, Interleukin-1?, NYHA Classification
Edition: Volume 11 Issue 12, December 2022,
Pages: 415 - 418