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Analysis Study Research Paper | Pathology | India | Volume 12 Issue 10, October 2023 | Popularity: 5.2 / 10
The Study on BCL2 Expression in Breast Carcinoma: Correlation with Predictive and Prognostic Factors
Dr. Aparna Mohanlal, Dr. Vivek George, Dr. Aditi Suseelan
Abstract: Breast cancer is a significant cause of mortality in Indian women, characterized by increasing incidence in younger individuals and heightened aggressiveness 1, 2. The understanding of molecular subtypes, especially those defined by hormone receptor expression (ER, PR, HER2), is pivotal for clinical management 3, 4. BCL2, a proto-oncogene, adds complexity as its overexpression in breast cancer paradoxically associates with improved survival 6. This study aims to investigate BCL2 expression in breast carcinoma and its relationship with other prognostic markers. A total of 83 breast cancer cases were analyzed, with immunohistochemistry conducted for ER, PR, HER2, and BCL2. BCL2 cytoplasmic expression in invasive breast carcinoma was correlated with established prognostic factors, including tumor size, histological grade, lymph node status, hormone receptor status (ER, PR), HER2 expression, and Nottingham prognostic index. Results revealed that 81.9% of participants were aged over 50, and 81.9% exhibited BCL2 positivity out of which 52.9% of the cases had grade 3 BCL2 staining intensity, 35.3% showed grade 2 positivity, and only 11.8% had grade 1 BCL2 staining intensity. Notably, BCL2 expression significantly correlated with ER and PR status (p < 0.05). In conclusion, this study highlights the intricate role of BCL2 in breast cancer and its connection with critical prognostic factors. The significant association of BCL2 with ER and PR positivity underscores its potential as both a prognostic and therapeutic marker in breast cancer 3.
Keywords: Breast Cancer, BCL2 Expression, Molecular Subtypes, Hormone Receptor Status
Edition: Volume 12 Issue 10, October 2023
Pages: 1033 - 1038
DOI: https://www.doi.org/10.21275/SR231011200156
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