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Research Paper | Cardiology Science | India | Volume 12 Issue 11, November 2023 | Popularity: 5.2 / 10

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A Study on Evaluation of Diagnostic Role of NT-proBNP in Heart Failure in Background of STEMI

Dr. Nasim Mondal, Dr. Bappaditya Kumar, Dr. Somnath Mukhopadhay

Abstract: We have evaluated the relationship between NT-proBNP levels and symptom onset, markers of reperfusion, size of infarct and prognosis in the STEMI patients. Objectives of the study: To study diagnostic role of NT-proBNP in ST segment elevation myocardial infarction patients complicated by heart failure, clinical profile of heart failure in STEMI patients and comparison between STEMI with heart failure and STEMI without heart failure. Study Area: Department of Cardiology, Medical college, Kolkata. Study Population: Patients with STEMI admitted in Medical college Kolkata. Study Period: One year (after ethics committee clearance). Sample Size: A minimum of 80 subjects. Results: In the present study 56 males(70%) and 24 females (30%) were involved and male and female ratio was 2.33:1. 1) Present study showed that males were more commonly affected by STEMI compared to female and STEMI was also more predominant in smokers. 2) We found thatthe heart failure group of subjects had mean CPK and CPK-MB higher in comparison to that in the group without heart failure. 3) It was found that NT pro-BNP was significantly increased in heart failure group compared to group without heart failure. 4) Our study found that LVIDD and LVIDS were higher in heart failure group compared to group without heart failure which was statistically significant. Mean (+/- SD) ejection fraction was significantly lower in heart failure group. 5) Heart failure was more common in the patients with AWSTEMI compared to IWSTEMI group and it was statistically significant. 6) Heart failure was more common in the patients with triple vessel coronary artery disease and it was statistically significant. 7) All patients of AMI with and without heart failure taken together(n=80) when studied it was found that the NT pro-BNP was positively correlated with LVIDD, LVIDS and severity of CAD in STEMI patients which was statistically significant. NT pro-BNP was negatively correlated with LVEF in STEMI patient and it was statistically significant. 8) In patients of AMI with systolic heart failure group only (n=40) NT pro-BNP was positively correlated with LVIDD, LVIDS and severity of CAD but NT pro-BNP was negatively correlated with LVEF which were not statistically significant. 9) In patients of AMI with diastolic heart failure only (n=10) NT pro-BNP was positively correlated with LVIDD, LVIDS and severity of CAD. It was also observed that NT pro-BNP was negatively correlated with LVEF though that was not statistically significant. 10) It seems that the NT-proBNP in acute coronary syndrome may be a very useful marker .There is a positive correlation between NT Pro BNP and the number of coronary artery (ies) involved and the severity of luminal stenosis. Last but not the least NT Pro BNP is a very valuable marker for predicting higher incidence of heart failure and lower ejection fraction.

Keywords: STEMI, Heart failure, NTproBNP

Edition: Volume 12 Issue 11, November 2023

Pages: 118 - 136

DOI: https://www.doi.org/10.21275/SR231029204831

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