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Research Paper | Pharmacology Science | India | Volume 12 Issue 11, November 2023 | Rating: 4.9 / 10
An Evaluation of Trigger Tool Method for Adverse Drug Reaction Monitoring at a Tertiary Care Hospital in Andhra Pradesh
Dr. Nandanavanam V N P Sai Sarath Chan | Attota Ratna Sowryaswi | Veesam Anantha Prakash
Abstract: Objectives: Trigger tool method (TTM) is an active surveillance method for adverse drug reaction (ADR) monitoring. The study aimed to evaluate TTM for ADR monitoring in in-patients of the surgery department. Material and Methods: This prospective, observational study was conducted at the Department of Surgery of a Tertiary Care Teaching Hospital in Kakinada, Andhra Pradesh. Preliminary trigger tool list (PTTL) comprising 13 drug triggers (DTs), 13 patient triggers (PTs), 9 laboratory triggers (LTs), and 12 surgical module triggers (STs) were used. Patients were followed up till discharge to monitor the occurrence of triggers and adverse events. Results: A total of 400 patients were included (male: female ratio of 2.3:1; mean age: 43.07 ? 16.4 years; and mean length of hospital stay: 5.75 ? 3.12 days). Of 400 patients, triggers were present in 359 patients (89.75%) and no trigger was observed in 41 patients (10.25%). Of the 47 triggers in PTTL, 24 triggers were observed 1155 times, of these 14 triggers lead to the detection of 49 ADRs in 43 patients. The rate of adverse drug events was 12.25/100 patients. DT was the most common trigger identified (81.64%). Positive predictive values (PPV) for PTs, STs, DTs, LTs were 26.88%, 23.07%, 10.3%, and 5.55%, respectively. The comprehensive PPV of PTTL was 11.97%. Modified trigger tool list consists of 14 triggers. Conclusion: TTM is an effective method of ADR monitoring in the surgery department. An awareness of TT helps better detection of ADRs.
Keywords: Adverse drug reaction, adverse drug reaction monitoring, pharmacovigilance, surgery, trigger tool method
Edition: Volume 12 Issue 11, November 2023,
Pages: 348 - 351