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Research Paper | Obstetrics and Gynecology | India | Volume 12 Issue 11, November 2023 | Popularity: 5 / 10

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To Evaluate the Predictive Value of Oxygen Saturation in Adverse Maternal Outcome in Women with Hypertensive Disorders of Pregnancy

Dr. Nidhi Johari, Dr. Varada Arora

Abstract: Background: Hypertension, perhaps, is the most common medical problem during pregnancy. In pregnancies complicated by hypertension, owing to compromised cardiac outputs and intravascular volumes, the oxygen saturation is affected more adversely and thereby could be responsible for adverse events during pregnancy. Owing to a high potential of causing hypoxia4, the role of oxygen saturation as a maker for adverse outcomes in pregnancies complicated by hypertension has generated interest among researchers in recent years5 Objectives: The present study targets to evaluate efficacy of oxygen saturation as a predictor of adverse outcome in women with hypertensive disorders in the pregnancy at a tertiary care centre in Northern India. Study Design: A total of 86 pregnant women with preeclampsia/hypertensive disorders in pregnancy (HDP) and gestational age >28 weeks were enrolled as cases and an equal number of matched pregnant women without preeclampsia/HDP were enrolled as controls. At admission oxygen saturation was measured. Adverse events within 48 hours and throughout the continuation of pregnancy were noted. Data was analyzed using SPSS 21.0 using Chi-square and Independent samples ?t?-test. Receiver-operator characteristic curves were also drawn. Results: Mean age of cases was 24.88?3.24 years. Majority of cases were gravida 1 (62.8%) and maximum (43.0%) presented at >37 weeks. There was no significant difference between cases and controls for age, gravid and gestational age. Incidence of adverse events in cases was 14% at 48 hr and 33.7% during the entire period. No adverse event was recorded in controls. Mean oxygen saturation of cases (94.57?2.60%) was significantly lower as compared to that of controls (99.19?1.10%). All the women having adverse events at 48 hour had oxygen saturation <95% while 25/29 (86.2%) of those having adverse events throughout the pregnancy. Oxygen saturation <93% was projected to have a sensitivity and specificity of 91.7% and 77% for adverse events at 48 hr and <94% had a sensitivity and specificity of 72.4% and 82.5% for adverse events throughout pregnancy. Conclusion: Despite a good sensitivity and specificity, we feel that the usefulness of oxygen saturation as the sole risk predictor may confound, however, hence usefulness of oxygen saturation in multivariate predictive models should be investigated further.

Keywords: Preeclampsia, hypertension during pregnancy, adverse events, oxygen saturation

Edition: Volume 12 Issue 11, November 2023

Pages: 820 - 825

DOI: https://www.doi.org/10.21275/SR231109145106

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