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Case Studies | Pathology | India | Volume 12 Issue 11, November 2023 | Rating: 5 / 10
EBV Associated Lymphoid Proliferation Masquerading as Acute Leukaemia: A Case Report
Harsh Bhalodiya | Arambam Gautam [3] | Jyotsna Huidrom | Ronal RK | Sushila L [2]
Abstract: Epstein Barr Virus (EBV) is the DNA virus which is implicated in the causation of benign as well as malignant lymphoid proliferation. The lymphoid proliferation caused by EBV may mimic acute leukaemia morphologically in the peripheral blood smear and in bone marrow aspirate findings. EBV is involved in the development of specific types of benign lymphoproliferation and malignant lymphomas. The virus mainly target the lymphoid cells, liver, spleen and lymph nodes of the body. The various manifestations of EBV infection may be mistaken as leukaemic malignancies. EBV infection may present asymptomatically or it may present as a fulminant form. It can also present as persistent EBV infection lifelong. Here , we present a case of pancytopenia presenting with fever, icterus, lymphadenopathy which was mimicking acute leukaemia clinically. Peripheral blood smear show some atypical cells and after bone marrow examination it turns out to be positive for EBV associated lymphoid proliferation. EBV infection may present as pancytopenia with clinical features suggestive of acute leukaemia.
Keywords: EBV, lymphoid, proliferation, lymphoma , pancytopenia , acute leukaemia
Edition: Volume 12 Issue 11, November 2023,
Pages: 1311 - 1312