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Research Paper | Biochemistry | India | Volume 12 Issue 12, December 2023 | Rating: 5.4 / 10
Correlation between Microalbuminuria and Glycated Hemoglobin in Type 2 Diabetes Mellitus
Dr. Ratna Priya | Dr. Chandan Kishore
Abstract: Background: DM is a worldwide public health problem and puts a substantial burden on health care resources. The chronic hyperglycemia of DM type 2 is associated with end-organ damage, dysfunction, and failure, including the retina, kidney, nervous system, heart, and blood vessels. Diabetic Nephropathy (DN) is the leading cause of premature deaths in diabetic patients due to renal failure. Mortality in diabetic patients with proteinuria is about 40 times higher than in diabetes without proteinuria. Glycated hemoglobin is the perfect and widely utilized biomarker of glycemic control in subjects with DM with higher concentration of glucose. The formation of the sugar-hemoglobin linkage indicates the presence of excessive sugar in the bloodstream, often indicative of diabetes in high concentration (HbA1c >6.4%). (11) A1C is of particular interest because it is easy to detect. Objective: Present study was aimed to estimate microalbuminuria, HbA1c in patients with type 2 DM and to find out the correlation of glycemic control with microalbuminuria. Materials and methods: A cross-sectional study is conducted at the Department of Medicine, Patna medical college, Patna. The duration of the study was from September 2021 to March 2022. A sample size of a total of 150 patients of type 2 DM was selected. A total of 150 patients fulfilling selection criteria was included by their consent in the study. Venous blood was collected after 12 hours of fasting in a test tube with ethylene diamine tetraacetic acid (EDTA) anticoagulant for HbA1c. The blood samples were analyzed for HbA1c, fasting blood glucose and postprandial blood glucose, serum urea and serum creatinine. Urine sample was analyzed for microalbumin. Result: In the present study, levels of HbA1c and microalbuminuria are higher in diabetics than in controls, and the elevations are of high statistical significance (P < 0.0001). In this study, it is found that diabetics with poor glycemic control had higher microalbumin levels compared with those of diabetics with good glycemic control. Conclusion: it is seen that there is an association of microalbumin levels with poor glycemic control (HbA1c). Similarly, this study also reveals that the diabetics? subjects having poor metabolic control are more prone to renal damage, and thus elevated microalbumin levels.
Keywords: microalbumin, HbA1c, glycated hemoglobin, diabetes mellitus, nephropathy
Edition: Volume 12 Issue 12, December 2023,
Pages: 164 - 167