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Research Paper | Gynaecology | India | Volume 12 Issue 12, December 2023 | Rating: 4.2 / 10
Evaluation of Visual Inspection by Acetic Acid, High Risk Human Papilloma Virus Testing and Human Papilloma Virus 16/18 Genotyping to Screen for Cervical Cancer in a Low Resource Setting
Divya Singh [4] | Gauri Gandhi
Abstract: Cancer Cervix screening has evolved over the years and newer modalities for cancer cervix are constantly emerging. This study was undertaken to analyse the sensitivity and specificity of VIA, HR HPV testing and HR HPV testing triaged by HPV 16/18 genotyping with Colposcopy and Biopsy as gold standard. Out of 402, 51 women (12.7%) were positive on one or more screening test and 12 women were identified with Cervical Intraepithelial Neoplasia (CIN 1 or worse). The sensitivity of Pap Smear, VIA, HR HPV, HPV triage and sequential testing was 58.3%, 91.7%, 88.3%, 90% and 75% respectively and the specificity was 86.4%,61.7%,79%,88.3% and 88.9% respectively. Thus, the best balance of sensitivity and specificity was of HR HPV triage with genotyping and Sequential testing. In countries where it is feasible, HR HPV testing as a primary test and triage with HPV 16/18 genotyping or VIA or cytology can be undertaken and in resource poor countries primary screening by VIA and sequential testing for HR HPV can be done for screening.
Keywords: Visual Inspection by Acetic Acid, Pap Smear, HPV testing, Cervical Intraepithelial Neoplasia
Edition: Volume 12 Issue 12, December 2023,
Pages: 849 - 852