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Research Paper | Pharmacy | India | Volume 13 Issue 1, January 2024 | Rating: 5.4 / 10
Evaluation of Antidepressant Activity of Apium Graveolens
Veeresh Babu Pratap | Rahul Patil [3] | Sowmya Amarthaluri | Gangaraju Mudunuri
Abstract: Depression, a prevalent neuropsychiatric disorder, continues to pose significant challenges in both diagnosis and treatment. Natural compounds from plants have gained attention as potential sources for novel antidepressant agents. Apium graveolens, commonly known as celery, is rich in bioactive phytochemicals and has demonstrated various medicinal properties. This study aimed to investigate the antidepressant potential of Apium graveolens using widely employed preclinical models, the Tail Suspension Test (TST) and the Forced Swim Test (FST). Male albino mice were subjected to treatments with Apium graveolens extract at two different doses (200 and 400 mg/kg), and their behavior was assessed using TST and DST. The results demonstrated a significant reduction in immobility time in the treated groups, indicating a potential antidepressant effect. The findings suggest that Apium graveolens may possess anti - depressant activity, warranting further exploration of its mechanisms and potential use as a natural remedy for depressive disorders. This research contributes to the growing body of evidence supporting the use of plant - derived compounds in mental health therapeutics and underscores the importance of investigating the potential of traditional medicinal plants as sources of novel antidepressant agents.
Keywords: Depression, Apium graveolens, Tail Suspension Test, Forced swim test, antidepressant
Edition: Volume 13 Issue 1, January 2024,
Pages: 1229 - 1236