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Research Paper | Medical Science | India | Volume 12 Issue 12, December 2023 | Popularity: 5.2 / 10

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A Perspective Double-Blind Randomized Multifactorial Clinical Study Comparing 2% Lidocaine and Adernaline With 4% Prilocaine and Felypressin

Sami Faisal Jamdar, Nasser Rashid Alsafi, Faisal Matar Alanezi, Mariam Alkhaldi, Nasser Alshammari, Mariam Alkhater, Mohammad Alkuhl

Abstract: Introduction: Lidocaine with Adrenaline and Prilocaine with Felypressin are both available from the Ministry of Health Saudi Arabia. However, both formulations are well documented and found to be clinically safe in numerous clinical studies. This study focused on determining the efficacy of 2% lidocaine and adrenaline in comparison with 4% prelocaine and felypressin local anesthetic agents for dental Extractions in completely healthy ASA class1 patients. Material and Methods: A total of 460 Patients (all ASA type 1) between age group 18 to 60 were divided into two main groups as group 1(lidocaine 2%) and group 2 (prilocaine 4%). These Two main groups were further divided into two subgroups Mg1 (Maxillary group) and Mg2 (mandibular group). The patients were randomized and equally distributed by an assisting nurse whereas the administrating physician and the patients were blind regarding the choice of anesthetic agent. In the Mg1 group the local anesthesia technique used was buccal and palatal infiltration, whereas in Mg2 group inferior alveolar nerve block and buccal infiltration were used. The comparison criteria were: 1) Latency or Onset of anesthesia, 2) The amount of anesthetic agent used, were 3) Need to re-anaesthetize the surgical zone (number of times), 4) Pain perception during procedure on a visual scale of 1 to 10, The results of each group were collected tabulated and subjected to statistical analysis. Results: The results showed that the onset of local anesthesia in buccal infiltration was better with Prilocaine 4% at 0.95 minutes, but time (anesthesia) required for achieving the full effect of local anesthesia was almost similar in both groups. Significant difference was found in the amount of anesthetic solution required to achieve full anesthesia. Prilocaine 4%was required in much higher quantity compared to Lidocaine 2%. Conclusion: In our study, we wanted to compare the success of anesthesia (absence of pain) in both groups. We found that Lidocaine with adrenaline was found to be more superior to prilocaine with felypressin for dental extractions. The amount of Anesthetic solution required to achieve full anesthesia was significantly higher in Prilocaine 4%. The higher number of injections causes discomfort to the patient so we recommend using Lidocaine 2% in healthy ASA class 1 patients.

Keywords: adrenaline, felypressin, lidocaine, local anesthesia, prilocaine

Edition: Volume 12 Issue 12, December 2023

Pages: 1244 - 1249

DOI: https://www.doi.org/10.21275/SR231214040843

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