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Research Paper | Pharmacy | India | Volume 12 Issue 12, December 2023 | Rating: 5 / 10
Evaluating the Anti-inflammatory Properties of D. Hookeri Rhizome Extract: Insights from an In-Vivo Study
Shubham Wani | Rekha Gour [3] | Anant K. Patel [2]
Abstract: Inflammation occurs as defensive response, which include physiological adaptions to limit tissue damage and remove the pathogenic infections. The ethanolic rhizome extract of D. Hookeri was assessed for its in-vivo anti-inflammatory activity. The unfavourable consequences of synthetic medications for treating acute inflammatory diseases serve as a powerful incentive for scientists to create novel medications with fewer side effects. The soxhlation extraction technique was used to obtain ethanolic extract and the yield of the ethanolic extract of D. Hookeri's rhizomes was 28.27% w/w. The rhizomes of the ethanolic extract of D. Hookeri included alkaloids, saponins, tannins, flavonoids, glycosides, phenolic content, terpenoids, and volatile oils, according to the qualitative preliminary phytochemical screening. The anti-inflammatory efficacy of the ethanolic extract was evaluated against carrageenan induced rat paw edema at different doses (200 and 400mg/kg body weight) orally while indomethacin 10 mg/kg served as standard. The changes in the paw volume of rats were measured using mercury Plethysmometer. The significant anti-inflammatory activity was exhibited in the rats (p<0.05) by decreasing the paw edema volume. The % inhibition of paw edema by 400mg/kg body weight of the ethanolic extract of D. Hookeri extract at 5th hour was 38.14% while the Indomethacin treated rats showed 40.20% inhibition of paw edema. The study's findings support the use of this plant in the management of disorders associated with inflammatory diseases.
Keywords: Inflammatory activity, Plethysmometer, rhizomes of D. Hookeri, Indomethacin
Edition: Volume 12 Issue 12, December 2023,
Pages: 1250 - 1254