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Research Paper | Biomedical Sciences | Indonesia | Volume 12 Issue 12, December 2023 | Popularity: 5.3 / 10

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Biochemical Profile of White Rat Blood during Mating and Pregnancy Treated with Steeping Water of Dried Gedi Leaves (Abelmoschus manihot)

Dingse Pandiangan, Michael Vallery Loueis Tumbol, Nelson Nainggolan, Elvina Artha Nainggolan, Ivana Cristy Nainggolan, Verina Putri Nainggolan

Abstract: This study aimed to investigate the blood biochemical profile of white rats (Rattus norvegicus) during the mating process and pregnancy given water treatment steeping dried gedi leaves (Abelmoschus manihot). White rats are a commonly used animal model in biomedical and reproductive research. The research method involved the selection of female white rats which were divided into two groups, namely the control group given plain water and the treatment group given water steeping dried gedi leaves for 34 days. Blood measurements are carried out 3 times. Biochemical parameters evaluated include blood glucose levels, total cholesterol, triglycerides, uric acid, HDL, LDL, AST/SGOT, and creatinine. The results showed that the group of rats that received water treatment steeping dried gedi leaves experienced a decrease in glucose, total cholesterol, and AST/SGOT. This decrease is perfect for using Gedi steeping water as a health supplement. However, the biochemical profile is improved in uric acid, HDL, LDL, and creatinine. A good increase in blood content is HDL and decrease of AST/SGOT, glucose, total cholesterol which can potentially be hepatoprotective and anti-degenerative. However, the increase in uric acid, creatinine and LDL during 34 days of treatment is an indication of side effects of steeping water that need to be considered in the future in production development. The steeping water treatment group in the blood biochemical profile was significant compared to the control group. Blood glucose levels experienced different fluctuations during the mating and pregnancy periods in the treatment group. Changes in these biochemical parameters can have important implications for reproductive development and the health of pregnant women.

Keywords: Biochemical profile, Gedi, Abelmoschus manihot, HDL, LDL, Rat

Edition: Volume 12 Issue 12, December 2023

Pages: 2003 - 2013

DOI: https://www.doi.org/10.21275/SR231229102353

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