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Research Paper | Toxicology Science | Saudi Arabia | Volume 12 Issue 2, February 2023 | Rating: 5.5 / 10
Effect of the Nutritional Supplement Synertox on Lead - Induced Toxicity in Male Albino Rats
Mohammed Al - Zhrani | Mohammed Mubarak | Hassan Ahmed Rudayni | Mohammed Al - eissa
Abstract: Background: Synertox is a supplement of high nutritional value containing a cocktail of highly rich ingredients. Lead is one of the well-known hazardous heavy metals. The current study was conducted to investigate the probable role of synertox to ameliorate the lead-induced toxic effects. Materials and Methods: For this purpose, 60 male albino rats were randomly divided into 3 groups, of 20 animals each, designated groups 1, 2 and 3. Rats in group 1 served as untreated control, group 2 animals were intoxicated by lead and group 3 rats were exposed to lead and received synertox in their drinking water. Results: All hematological and biochemical parameters were altered in the lead intoxicated rats (group 2) compared to control group. Addition of synertoxin group 3 resulted in increasing the erythrocytic indices, including RBCs count, hemoglobin concentration and hematocrit %. Biochemical parameters of group 3 disclosed comparatively increased levels of total proteins and decreased levels of creatinine, urea, bilirubin and serum enzymes in relation to the levels recorded in group 2 (lead intoxicated animals). Conclusion: It was concluded that synertox as a highly concentrated nutritional supplement may provide an ameliorating effect on the lead induced toxicity as judged by the encountered hematological and biochemical profiles.
Keywords: Lead toxicity, synertox, antioxidant, hematological changes, biochemical Profile
Edition: Volume 12 Issue 2, February 2023,
Pages: 35 - 39