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Research Paper | Emergency Medicine | India | Volume 12 Issue 2, February 2023 | Popularity: 5.5 / 10
Utility of Serum Neurofilament Light Protein as a Biomarker in Traumatic Brain Injury
Shalini Pasupuleti, Satish Kumar Putta, Vamsi Krishna Yerramneni, Ashima Sharma
Abstract: Objective: Traumatic Brain Injury (TBI) is the most predominant cause of morbidity globally. The load of TBI in all age groups leads to a raise in the cost of treatment. The addition of blood biomarkers can provide more reliable information about neuronal injury and can aid clinical evaluation without sacrificing sensitivity. They may also serve as cost - effective tools with good specificity of TBI. Methodology: 34 severe TBI patients between 2019 to 2020, admitted to Nizam?s Institute of Medical Sciences, Hyderabad, India were enrolled.30 orthotrauma patients (OT) and 30 Healthy controls were also included in the study. All the participants were assessed for serum levels of Neurofilament Light protein (NFL) and S100B. Results: Serum NFL and S100B concentrations of the severe TBI patients on day 0 ranged from 150.8 to 414.6 pg/ml and 705.26 to 3747.37 pg/L. The NFL was markedly higher in severe TBI patients than Healthy controls and OT patients. The values at d0 after injury of NF - L (p=0.012) and S100B (p=0.202) and over the hospital stay were significantly higher in non survivors vs. survivors. Conclusion: NFL would help for better prognostication in TBI patients. Measurement of NFL in serum may be useful to assess the axonal degeneration by knowing the severity of TBI especially in long term impairment, Whereas, S100b can be useful to diagnose the disease.
Keywords: Traumatic brain injury, Neurofilament light protein, s100b, axonal injury, orthotrauma patients
Edition: Volume 12 Issue 2, February 2023
Pages: 468 - 473
DOI: https://www.doi.org/10.21275/SR23131154730
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Emergency Medicine, India, Volume 12 Issue 10, October 2023
Pages: 18 - 24Evaluating the Clinical Significance of ICH Score in the Management of Intracerebral Hemorrhage: A Prospective Study in Karnataka, India
Keerthana S, Rajanikanth S Malapur, Vijayalakshmi P B
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Emergency Medicine, India, Volume 11 Issue 8, August 2022
Pages: 621 - 626Study of Associations between ABO Blood Group and COVID-19 Infection, ICU Need and Death in a Tertiary Care Centre
Punith K G, Bharath Angadi, Manjunatha B H, Rajnikanth S Malapur, Vijayalakshmi P B, Akshaya Ananthanarayanan
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Emergency Medicine, India, Volume 12 Issue 3, March 2023
Pages: 851 - 853Lactate Albumin Ratio in Comparison with Lactate to Predict Outcomes in Sepsis and Septic Shock
Albee, Anurag Prasad, Tapas Tripathi, Mohd Junaid Khan
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Emergency Medicine, India, Volume 12 Issue 6, June 2023
Pages: 846 - 851Assessing First Pass Success Rate with Low Dose Rocuronium during Rapid Sequence Intubation among Patients in an Emergency Department
Dr. Jerin Miriam Johnson, Dr. Jobin Jose Maprani, Dr. Yasir Sulaiman, Dr. Vaisakh R Vijay, Dr. Jeevan Jayakumar