Downloads: 0 | Views: 185
Comparative Studies | Medicine | India | Volume 12 Issue 2, February 2023 | Popularity: 4.7 / 10
Intravenous Iron Sucrose versus Oral Iron in Treatment of Iron Deficiency Anemia in Pregnancy: A Randomized Clinical Trial
Akashkumar Dongarwar, Tejas Kotecha, Maya Arvikar
Abstract: Aim: Iron deficiency is a leading cause of anemia in pregnancy. The present study aimed to compare the efficacy of oral and intravenous iron therapy in improving iron deficiency anemia in pregnancy and restoring iron stores, compare the obstetric outcome in the two groups and evaluate the safety of intravenous iron sucrose. Material and Methods: This was a prospective study, where 100 anemic antenatal women with hemoglobin 7-9 g/dL, mean corpuscular volume <85 fL and serum ferritin <15 ng/mL, were randomized into two groups. In group A (n = 50), the women received 200 mg tablets of ferrous sulphate, each containing 60 mg elemental iron, three times a day for 4 weeks. In group B (n = 50), iron sucrose was given in divided doses of 200 mg each on alternate days by slow intravenous infusion. Primary outcome measure was treatment efficacy, assessed by measurement of hemoglobin, red blood cell indices and reticulocytes on days 7, 14, 21, and 30 and at delivery, and of ferritin on day 30 and at delivery. Any side-effects of treatment and the neonatal outcome were studied as secondary outcome measures. Results: There was a statistically significant difference in increase of hemoglobin levels (3.1 g/dL in group A vs 5.1 g/dL in group B; P = 0.002) and ferritin levels between the two groups on day 30 (P = 0.005). The adverse effects from iron treatment were mild but more prominent in group A. Neonatal outcome was comparable in the two groups. Conclusion: Intravenous administration of iron sucrose is a safe treatment for correction of anemia in pregnancy, without serious side-effects.
Keywords: anemia, intravenous iron sucrose, iron deficiency, oral iron sulphate, pregnancy
Edition: Volume 12 Issue 2, February 2023
Pages: 920 - 924
DOI: https://www.doi.org/10.21275/SR23214214820
Make Sure to Disable the Pop-Up Blocker of Web Browser
Similar Articles
Downloads: 4 | Weekly Hits: ⮙2 | Monthly Hits: ⮙2
Case Studies, Medicine, Indonesia, Volume 10 Issue 4, April 2021
Pages: 1228 - 1231Pregnancy with Von Willebrands Disease: A Case Report
I Gede Bagus Garjita Maesa Putra, Anak Agung Gede Putra Wiradnyana
Downloads: 0
Research Paper, Medicine, Uzbekistan, Volume 9 Issue 11, November 2020
Pages: 1692 - 1696Comparative Characteristic of Population Mechanisms for Formation of Iron Deficiency States among the Drugging Population
Mamasaliev Ne'matjon Solievich, Usmonov Burkhonjon Umarovich, Kurbanova R. R.
Downloads: 0
Doctoral Thesis, Medicine, India, Volume 11 Issue 5, May 2022
Pages: 1705 - 1709Evaluation of Anaemia in Type 2 Diabetes Mellitus Patients with Special Reference to Vitamin B12 Deficiency
Dr. Krithika .K, Dr. Subha Lakshmi Das
Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Medicine, Indonesia, Volume 10 Issue 12, December 2021
Pages: 1333 - 1336Differences in Initial Lactate Levels on Elderly and Non-Elderly Sepsis Patients Associated With Sofa Score as a Predictor of Mortality in ICU RSUP H. Adam Malik
Febrina Sulaiman, Achsanuddin Hanafie, Adi Koesoema Aman
Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Technical Report, Medicine, India, Volume 12 Issue 11, November 2023
Pages: 763 - 766A Case of Thrombotic Thrombocytopenic Purpura
Dr. A Sankar, Dr. Umashankar, Dr. S. Adhitya Surya