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Research Paper | Anaesthesiology | India | Volume 12 Issue 2, February 2023 | Rating: 5 / 10
Comparative Study on Intubating Conditions and Neuromuscular Blocking Effect of Two Different Doses of CIS - Atracurium
Dr Arun Andappan | Dr Anshika Gier | Dr Khobragade Sneha Dasharath | Dr Ramesh Kumar Malaichamy
Abstract: Our study was a comparative study for assessment of intubating conditions with two different doses of cisatracurium, a non - depolarising neuromuscular blockade safer comparable to other drugs of same group. The study was conducted on 50 patients (25 in each group with two doses) posted for elective laparoscopic cholecystectomy under general anaesthesia. The primary outcome of the study was assessing the intubating condition and neuromuscular blocking effect in two different doses of cisatracurium. The result of the study showed that in group A, 18 (72%) patients had excellent intubating conditions and 7 (28%) patients had good intubating conditions. On the other hand in group B, all the patient i. e., 25 (100%) had excellent intubating conditions. No patients were found to have poor or impossible intubation. The principal advantage of cisatracurium is the lack of histamine release which provides better cardiovascular stability compared to atracurium and other histamine releasing neuromuscular blocking agents. Both the doses were associated with stable hemodynamics without statistically significant changes. Allergic reactions or, side - effects were not seen in either of them. Hence, because of faster onset and longer duration of action with larger doses of cisatracurium (0.2mg/kg) and stable hemodynamics, make cisatracurium a more promising alternative muscle relaxant agent for tracheal intubation in clinical practice. Also, higher dose of 0.2mg/kg can be considered in various scenarios including critically ill, to facilitate safe intubating conditions.
Keywords: CIS, Atracurium, Endotracheal Intubation, Neuromuscular blockade, Laryngoscopic view, Intubating Conditions
Edition: Volume 12 Issue 2, February 2023,
Pages: 1621 - 1624