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Research Paper | Pharmacy | India | Volume 12 Issue 3, March 2023 | Popularity: 5.1 / 10
Evaluation of Diuretic Activity of Desmodium gangeticum Linn
B. Madhulatha, Dr. Akhlesh K. Singhai
Abstract: Purpose: The present study was undertaken to investigate diuretic effect of methanol extracts of the roots of Desmodium gangeticum L., in normal rats. Method: methanol extract of Desmodium gangeticum L. were administered to experimental rats orally at various doses (100mg/kg, 200mg/kg, 400mg/kg) p.o. Furosemide (10 mg/kg) was used as positive control in the study. The diuretic effect of the extracts was evaluated by measuring urine volume, diuretic index and Lipschitz value, sodium and potassium content, and chloride content. Saluretic index, Natriuretic index and Ion quotient were calculated. Result: Urine volume was significantly increased by the two doses of methanol extracts from root of Desmodium gangeticum L., in comparison to control group. While the excretion of sodium was also increased by both extracts, The highest dose of extract significantly excreted sodium, chlorides in excess and had good saluretic, natriuretic activity which was comparable to that of standard drug. There was no potassium sparing effect found. There was no significant change in the pH of urine but they were mildly alkaline after administration of the Desmodium gangeticum L., extracts. The diuretic effect of the extracts was comparable to that of the reference standard (Furosemide). Conclusion: We can conclude that methanol extracts of Desmodium gangeticum L., produced diuretic effect. Present study provides a quantitative basis for explaining the diuretic use of Desmodium gangeticum L., as a diuretic agent.
Keywords: Diuretic, urine volume, electrolytes, saluretic, natriuretic, diuretic index
Edition: Volume 12 Issue 3, March 2023
Pages: 415 - 420
DOI: https://www.doi.org/10.21275/SR23307083918
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