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Comparative Studies | Anaesthesiology | India | Volume 12 Issue 3, March 2023 | Rating: 5 / 10
A Comparative Study of Propofol Vs Midazolam for Sedation and Anti Emetic Effect in Spinal Anesthesia
Sunkesula Archana | Zainab N Attar [2] | Nagaswaroopa Kondareddy
Abstract: Background and objective: To compare Propofol and Midazolam for sedation and anti - emetic effect in spinal anesthesia. Methods and materials: This study was conducted in 130 patients of ASA grade I and II of both sexes in the age group of 18 - 60 years who were scheduled for various elective surgeries under spinal anesthesia. They were randomly allocated into 2 groups. Propofol group received Propofol in the dose of 0.75 - 1mg/kg body weight to maintain a sedation level 3 and repeated as necessary at a dose of 0.25 mg/kg and in midazolam group, Midazolam in the dose of 0.02mg/kg intravenous was given and repeated at a dose of 0.005mg/kg body as per requirement to maintain a sedation level 3. At the same time, the incidence of nausea and vomiting was alsoevaluated. Nausea and vomiting were evaluated using Bellville score. Results: Propofol appears to have a very rapid onset of sedation when compared to Midazolam. In this study, time of recovery in Propofol (78.46%) was faster when compared to Midazolam (53.8%) i. e,. within 2 - 3 minutes. Percentage of amnesia is more in Midazolam (61.5%) when compared to Propofol (41.5%) with p=0.023. Incidence of intraoperative nausea was less with Propofol group than Midazolam group. There is no significant difference in postoperative nausea in both groups at 30 mins intervals. The incidence of postoperative nausea was less with the propofol group than the midazolam group after 1 hour. Conclusion: Propofol gives rapid onset of sedation and faster recovery, while midazolam provides more hemodynamic stability in regional anesthesia. Propofol has lesser incidence of nausea and vomiting compared to midazolam.
Keywords: sedation, antiemetic, propofol, midazolam
Edition: Volume 12 Issue 3, March 2023,
Pages: 531 - 534