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Research Paper | Medicine | India | Volume 12 Issue 3, March 2023 | Rating: 5.1 / 10
FTIR & Acute, Subacte Toxicity Evaluation of Alli Chooranam (Nympheanouchali) burm. f)
Janani Syamaroopa Jnanathapaswini
Abstract: Aim of the study: Present study was undertaken to evaluate the acute, subacute toxicity & FTIR of hydroalcoholic extract (HEE) of powder of rhizome & flower of the plant Alli (Nympheanouchaliburm. f.) in rats. Materials and methods: Acute toxicity test was performed on Female wister rats at a single oral dose of 1 - 10?g/kg for 14 consecutive days. General behavioral adverse effects, mortality, and latency of mortality were determined. In the subacute study, the Alli chooranam (Nympheanouchaliburm. f.) extract was administered orally at doses of 300, 1000, and 2000?mg/kg daily for 28 days to Wistar rats. Body weight and selected biochemical and hematological parameters were determined at the end of the experiment. Sections of livers and kidneys were removed for histological studies. Results: Acute toxicity study showed that LD50 value of hydroethanolic extract of Alli chooranam (Nympheanouchaliburm. f.) is superior to 2000mg/kg. The subacute toxicity study of Alli chooranam (Nympheanouchaliburm. f.) extract at doses 300, 1000, and 2000?mg/kg did not produce any observable symptoms of toxicity and no significant variation in body weight, organ weights, food, and water consumption or mortality in all treated rats. Conclusion: Results indicated no toxicity of hydroalcoholic extract of powder of rhizome & flower of the Alli chooranam (Nympheanouchaliburm. f However, further toxicity assessments should be done to ascertain the safety or the toxicity of this valuable plant species Nympheanouchaliin sub chronic treatments.
Keywords: Alli, Nymphaea, FTIR, acute, subacute, Siddha
Edition: Volume 12 Issue 3, March 2023
Pages: 904 - 910