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Masters Thesis | Genomic Sciences and Bioinformatics | India | Volume 12 Issue 4, April 2023 | Popularity: 5.1 / 10
Protein Structure Prediction and Examination of Nucleocapsid Protein from SARS - COV2 using Computational and Simulation Tools
Aakash, Ryali Bhargavi Sri Vidya, Dr. Ajijur Rehman
Abstract: Recently emergency of COVID - 19 Corona virus has resulted in WHO declared public health issues and international emergency concern. The purpose of research globally around they working towards establishing a great understanding of this particular viruses and developing treatments and vaccinations all over the world to prevent spread. Structural properties of a protein it provides an important resource for understanding how it functions. This paper provides structural details of Nucleocapsid Protein (s) of novel corona virus. The Nucleocapsid protein of ncov2 is prominent for confining with a cell receptor which is act as referee for the synthesis of virus and host membranes, and these activities being crucial for virus ingress in to the host cell. This paper studies primary, secondary and tertiary structures of Nucleocapsid protein of SARS - COV2 predicted using Expasy Program, PSIPRED, and Homology Modelling Methods respectively. The predicted structure was validated using PROCHECK by Ramachandran plot and also validated through ProSAWeb tool. Finally, this predicted structure will helping and to discovering efficient medicine against corona epidemic. In future, result of the structure homology modelling would be energy minimized and can - do MD (Molecular dynamics) simulations to examine the how they expected model behave structurally, dynamically, using several computational and simulation tools.
Keywords: Nucleocapsid Protein, Secondary Structure Prediction, Tertiary Structure Prediction, PSIPRED, Homology Modelling, PROCHECK, Protparam, Compute pI Molecular Dynamics
Edition: Volume 12 Issue 4, April 2023
Pages: 799 - 817
DOI: https://www.doi.org/10.21275/SR23411190029
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