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Comparative Studies | Dental Medicine | India | Volume 12 Issue 4, April 2023 | Rating: 5.2 / 10

Evaluation of Salivary Lactate Dehydrogenase in Oral Submucous Fibrosis & Its Correlation with Clinical Submucous Fibrosis

Maggi Slany | Natarajan Kannan

Abstract: Introduction: Oral submucous fibrosis (OSMF) is a premalignant condition characterized by juxta epithelial inflammatory reaction, increased deposition of sub mucosal collagen and formation of fibrous bands in the oral mucosa which results in difficulty in mouth opening. Aim: To assess whether Salivary Lactate Dehydrogenase can be an effective biomarker for identifying dysplastic changes associated with oral submucous fibrosis and also to assess if any correlation exist between salivary LDH levels and clinical stage of oral submucous fibrosis. Methodology: 15 patients with OSMF (group A) were selected as study group and 15 healthy patients were selected as controls (group B). Salivary LDH level assessment and clinical staging of the OSMF were done and compared between the groups. Results: salivary LDH was greater in group A than group B. The mean LDH value of patients with grade I OSMF 270.14 U/L; the mean LDH value of patients with grade II OSMF 554.37 U/L. The mean LDH value in control group were 229 U/L. Higher LDH values were seen in OSMF grade II than grade I. Among the OSMF patients, LDH was found to be higher in patients with more severe stages of OSMF though the difference was statically significant. Conclusion: Our study showed, salivary LDH was good biomarker shows good correlation with staging of OSMF.

Keywords: Oral submucous fibrosis, salivary lactate dehydrogenase, saliva, premalignant conditions

Edition: Volume 12 Issue 4, April 2023,

Pages: 1242 - 1244