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Analysis Study Research Paper | Pediatrics | India | Volume 12 Issue 4, April 2023 | Popularity: 5.3 / 10
A Cross - Sectional Study of Renal Profile in Pediatric Patients with Sickle Cell Disease
Dr. Dhruti Patel, Dr. Omprakash Shukla
Abstract: Introduction: Sickle cell disease (SCD) is the most common hemoglobinopathy worldwide. It occurs due to a mutation in the ? - globin gene located on the short arm of chromosome 11. Blockages of the small blood vessels due to sickle shape RBCs cause tissue infarction and intermittent vaso - occlusion, which are responsible for acute or chronic organ damage and organ dysfunction. Renal disease is one of the most frequent complications which starts very early and progresses throughout life causing severe complications. Objective: To study the renal function status of Pediatric patients with SCD and to detect early renal abnormalities through blood investigations, urine analysis, and ultrasonography. Methodology: A cross sectional study was conducted at the Hematology clinic and Pediatric ward of SSG Hospital and Medical college, Vadodara, Gujarat for a period of one year. A total of 100 SCD patients were enrolled and detailed clinical history, laboratory investigations, and ultrasound were performed. Results: There were 68% male and 32% female with a ratio being 2.1: 1 enrolled in the study with a mean age of 8.71 ? 3.38. Mean urea was 27.68 ? 18.9, mean creatinine was 0.71 ? 0.4, mean urine PH was 6.32 ? 0.57 with specific gravity 1.01 ? 0.005.65% had abnormal FeNa values.35% had hepatomegaly, 42% had splenomegaly, 13% had both hepatosplenomegaly and 7% had reduced kidney size. On further evaluation 4% had Proteinuria, 2% had Hematuria. According to CKD - EPI classification 23% had a normal renal function, 55% had mild, 15% had moderate, 3% had severely decreased GFR, and 4% had hyperfiltration. Conclusion: According to CKD - EPI classification 23% of the enrolled patients had a normal renal function, 55% had mild, 15% had moderate, 3% had severely decreased GFR and 4% had hyperfiltration. As age increases GFR decreases, and this was statistically proved by the p - value 1.3 ? 10 - 19 ANOVA test. Proteinuria and hematuria were seen in 4% and 2% respectively in enrolled patients with normal mean urea and creatinine value.
Keywords: Sickle cell disease (SCD), CKD - EPI, GFR, HbF, hydroxyurea
Edition: Volume 12 Issue 4, April 2023
Pages: 1548 - 1551
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