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Research Paper | Biomedical Sciences | India | Volume 12 Issue 4, April 2023 | Popularity: 5.7 / 10

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Serum Testosterone Levels and Coronary Artery Disease

Niketa Ashem, Laikangbam Shaini, Thokchom Sachindeba Singh, Laithangbam Rosyka, Priyanka Maisnam, Kshetrimayum Roshita Devi

Abstract: Introduction: Coronary Artery Disease (CAD) is the leading cause of death worldwide. Testosterone has protective effect on cardiovascular system (CVS). Men are more prone to develop CAD than women and the mechanism of this different susceptibility is not well understood. Objectives: To estimate the concentration of serum testosterone levels in male subjects with and without CAD and to determine the relationship between serum Testosterone levels and angiographic severity of CAD. Methodology: A cross - sectional study, consisting of 110 subjects out of which 55 subjects diagnosed with CAD and 55 healthy subjects, was carried out in the department of Biochemistry in collaboration with the department of Cardiology of RIMS, Imphal from January 2021 to October 2022. Serum free and total testosterone levels were measured and the severity of CAD was assessed using angiographic Gensini score. Result: The mean ? SD of serum total and free testosterone levels were significantly lower in case group (2.05 ? 1.18 ng/ml, 3.79 ? 2.71 pg/ml) when compared to control group (4.97 ? 0.65 ng/ml, 16.22 ? 4.60 pg/ml). Cases with Gensini score >30 had significantly lower total testosterone levels and free testosterone levels than cases whose Gensini score were ?30. A multiple linear regression analysis showed that low testosterone was an independent risk factor the severity of CAD (?= - .238, p=.014). Conclusion: Men with coronary artery disease have significantly lower testosterone than normal controls. This study also suggests low serum testosterone as an independent risk factor for CAD.

Keywords: Testosterone, Coronary Artery Disease, Gensini Score

Edition: Volume 12 Issue 4, April 2023

Pages: 1807 - 1811

DOI: https://www.doi.org/10.21275/SR23428011625

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